If you want to compare you would first need to join them to the same dataset.
For it to be highlighted of a difference you would need to add some logic. Essentially you would have four columns I’m assuming, colA_1, colB_1, colA_2, colB_2. They would each be from two datasets. Then if you want to check it like such you would make a calculate field that goes like such.
ifelse(colA_1=colA_2 AND colB_1<>colB_2,‘Highlight’,‘No Highlight’)
Then you would add conditional formatting to the table to check for a highlight.